LEAD OPTIMIZATION


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HTS & MTS

Primary Screening for Hit Identification:

- in silico screening

- Biochemical screening

- Cell-based screening

Secondary Screening for Hit Confirmation:

- IC50/EC50 determination

- Counter and off target selectivity screening

SAR Screening (hit expansion and triage)

Ligand Profiling

LTS

in vivo preclinical screening (animal models):

- Invertebrates: C. elegans (larvae and adults)

- Vertebrates: Zebrafish (larvae)

- Early safety assessment screening

- ADMET screening

Preclinical candidate selection

NMR & ESR

Spectroscopy

Imaging